Hydrochloric Acid → HCID 66727435, compound

HRID 1423063Notes

Reaction equation

HRID 1423063 reaction equation
[CH3:1][S:2]([C:5]1[N:10]=[CH:9][C:8]([C@@H:11]([NH:14]S(C(C)(C)C)=O)[CH2:12][CH3:13])=[CH:7][CH:6]=1)(=[O:4])=[O:3].[ClH:21].O1CCOCC1>CO>[ClH:21].[CH3:1][S:2]([C:5]1[N:10]=[CH:9][C:8]([C@@H:11]([NH2:14])[CH2:12][CH3:13])=[CH:7][CH:6]=1)(=[O:4])=[O:3]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 66727572HCID 66727572, compound

Product 1

HCID 66727435HCID 66727435, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 2-methyl-propane-2-sulfinic acid [(S)-1-(6-methanesulfonyl-pyridin-3-yl)-propyl]-amide (50.0 g, 157 mmol) in methanol (500 mL) is added a 4 N solution of HCl in dioxane (40 mL, 160 mmol). After 1 hour, the mixture is concentrated to near dryness (about 40 mL) and the resulting mixture is diluted with ether (500 mL) and the solid is collected by filtration to afford the title compound.

Workup

  1. concentrationthe mixture is concentrated to near dryness (about 40 mL)
  2. additionthe resulting mixture is diluted with ether (500 mL)
  3. filtrationthe solid is collected by filtration

Sources & evidence

ORD record
ord-dd26a48f8f674642ae79376ac0e305cb
Source dataset
uspto-grants-2015_01
Patent number
US08927550B2

Reaction notes

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