Dichloromethane → HCID 86700901, compound

HRID 1424359Notes

Reaction equation

Br[CH2:2][C:3]([C:5]1[O:6][C:7]2[CH:13]=[C:12]([F:14])[CH:11]=[C:10]([O:15][CH2:16][C:17]3[N:18]=[C:19]([C:22]4[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=4)[S:20][CH:21]=3)[C:8]=2[CH:9]=1)=O.[Br:28][C:29]1[S:33][C:32]([NH2:34])=[N:31][N:30]=1.ClCCl.C([O-])(O)=O.[Na+]>CC(O)C>[Br:28][C:29]1[S:33][C:32]2=[N:34][C:3]([C:5]3[O:6][C:7]4[CH:13]=[C:12]([F:14])[CH:11]=[C:10]([O:15][CH2:16][C:17]5[N:18]=[C:19]([C:22]6[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=6)[S:20][CH:21]=5)[C:8]=4[CH:9]=3)=[CH:2][N:31]2[N:30]=1

Participants

Conditions

Temperature: 150 °C

Procedure

In a 2-5 mL microwave pressure vial was added 2-bromo-1-(6-fluoro-4-((2-phenylthiazol-4-yl)methoxy)benzofuran-2-yl)ethanone (Example 36E, 35 mgs, 0.078 mmol) in propan-2-ol (2 mL) followed by 5-bromo-1,3,4-thiadiazol-2-amine (16.2 mgs, 0.09 mmol). The reaction was heated to 80° C. overnight and to 150° C. for 1 h in microwave oven. The reaction mixture was then poured into a mixture of dichloromethane (8 mL) and saturated NaHCO3 (2 mL) and this was extracted twice with dichloromethane. The organic extracts were dried over MgSO4, filtered and concentrated. The residue was purified by silica gel chromatography (ISCO 12 g gold column using 100% dichloromethane, then 1% ethyl acetate and then 2% ethyl acetate in dichloromethane) to give the title material (18 mgs, 43%) as a yellowish solid. LC (Method B): 2.754 min. LCMS (APCI) calcd for C22H13BrFN4O2S2 [M+H]+ m/z 526.96. found 527.0.

Workup

extractionthis was extracted twice with dichloromethane
dry with materialThe organic extracts were dried over MgSO4
filtrationfiltered
concentrationconcentrated
customThe residue was purified by silica gel chromatography (ISCO 12 g gold column

Sources & evidence

ORD record: ord-0f6b1925df824ee59601862f24a1b429
Source dataset: uspto-grants-2015_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08927688B2

Reaction notes

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