Dimethylformamide → 4-Fluoro-2-(4-fluorophenyl)-5-(4-methoxy-2-methyl-5-(1-(5-methylpyrimidin-2-yl)cyclopropylcarbamoyl)phenyl)-N-methylbenzofuran-3-carboxamide

HRID 142474Notes

Reaction equation

HRID 142474 reaction equation
[CH3:34][c:35]1[cH:36][n:37][c:38]([C:41]2([NH2:44])[CH2:42][CH2:43]2)[n:39][cH:40]1.[CH3:45][CH2:46][N:47]([CH2:48][CH3:49])[CH2:50][CH3:51].[F:1][c:2]1[c:3](-[c:22]2[c:23]([CH3:33])[cH:24][c:25]([O:31][CH3:32])[c:26]([C:27](=[O:28])[OH:29])[cH:30]2)[cH:4][cH:5][c:6]2[c:7]1[c:8]([C:18]([NH:19][CH3:20])=[O:21])[c:9](-[c:11]1[cH:12][cH:13][c:14]([F:17])[cH:15][cH:16]1)[o:10]2.[O:52]=[CH:53][N:54]([CH3:55])[CH3:56]>>[F:1][c:2]1[c:3](-[c:22]2[c:23]([CH3:33])[cH:24][c:25]([O:31][CH3:32])[c:26]([C:27](=[O:28])[NH:44][C:41]3([c:38]4[n:37][cH:36][c:35]([CH3:34])[cH:40][n:39]4)[CH2:42][CH2:43]3)[cH:30]2)[cH:4][cH:5][c:6]2[c:7]1[c:8]([C:18]([NH:19][CH3:20])=[O:21])[c:9](-[c:11]1[cH:12][cH:13][c:14]([F:17])[cH:15][cH:16]1)[o:10]2

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 8471TriethylamineHCID 592754645-(4-Fluoro-2-(4-fluorophenyl)-3-(methylcarbamoyl)benzofuran-5-yl) 2-methoxy-4-methylbenzoic acidHCID 67292523HCID 67292523, compound

Product 1

HCID 534682464-Fluoro-2-(4-fluorophenyl)-5-(4-methoxy-2-methyl-5-(1-(5-methylpyrimidin-2-yl)cyclopropylcarbamoyl)phenyl)-N-methylbenzofuran-3-carboxamide

Sources & evidence

ORD record
ord-b432d49eb3674ca1ae8b37821accfb22
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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