反应详情

2-Bromo-pentan-3-one obtained in Example (15a) (8.47 g, 35.57 mmol) was dissolved in DMF (120 mL). Potassium phthalimide (6.9 g, 37.25 mmol) was added, and the mixture was stirred at room temperature for 10 hours. Ethyl acetate was added to the reaction solution, and the organic layer was washed with 1 N hydrochloric acid and brine, and dried over anhydrous sodium sulfate. Following concentration under reduced pressure, the residue was washed with hexane to obtain 6.5 g of the title compound as a white solid (79%).

1. washthe organic layer was washed with 1 N hydrochloric acid and brine
2. dry with materialdried over anhydrous sodium sulfate
3. concentrationconcentration under reduced pressure
4. washthe residue was washed with hexane