反应详情

The same operation as in Example (221c) was performed using ethyl 2-(3-aminoazetidin-1-yl)-1,3-benzothiazole-6-carboxylate obtained in Example (225c) (190 mg, 0.69 mmol), 4-chloro-5-ethyl-1H-imidazole-2-carboxylic acid obtained in Example (1d) (132 mg, 0.75 mmol), WSC hydrochloride (394 mg, 2.06 mmol), 1-hydroxybenzotriazole (102 mg, 0.75 mmol) and N-methylmorpholine (0.15 mL, 1.37 mmol), to obtain 126 mg of the title compound as a milk white solid (42%).