Hydrochloric Acid → HCID 86646413, compound

HRID 1425609Notes

Reaction equation

HRID 1425609 reaction equation
[C:1](Cl)(=[O:19])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8]/[CH:9]=[CH:10]\[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18].[F:21][C:22]([F:26])([F:25])[CH2:23][OH:24].Cl>>[C:1]([O:24][CH2:23][C:22]([F:26])([F:25])[F:21])(=[O:19])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8]/[CH:9]=[CH:10]\[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 64092,2,2-TrifluoroethanolHCID 5364783Oleoyl chloride

Product 1

HCID 86646413HCID 86646413, compoundYield 96.1%

Procedure

Oleoyl chloride (75 g, 250 mmol) is heated at reflux with 2,2,2-trifluoroethanol (60 g, 600 mmol) for 16 hrs. After the evolution of HCl ceased, excess trifluoroethanol is removed in vacuo. Vacuum distillation of the residue afforded 87.6 g of 2,2,2-trifluoroethyl oleate as colorless liquid, bp 150°/0.3.

Workup

  1. customexcess trifluoroethanol is removed in vacuo
  2. distillationVacuum distillation of the residue

Sources & evidence

ORD record
ord-685b246adf584420aaee0d23a51af887
Source dataset
uspto-grants-2015_01
Patent number
US08932638B2

Reaction notes

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