反应详情

温度

80 °C

To a solution of 1-[2-(4-bromomethyl-2-methyl-phenyl)-2-oxo-ethyl]-4-(5-bromo-pyridin-2-ylmethoxy)-1H-pyridin-2-one (preparation 4b, 100 mg, 0.20 mmol) in DMF (2 mL) is added (R)-2-hydroxymethylpiperidine hydrochloride (75 mg, 0.50 mmol) and K2CO3 (55 mg, 0.40 mmol). The reaction mixture is stirred 2 h at 80° C. The mixture is purified via reverse phase HPLC chromatography (Phenomenex Gemini-C18 10 μm, gradient 5%→90% acetonitrile in water+0.3% NH4OH, 120 mL/min).

1. customThe mixture is purified via reverse phase HPLC chromatography (Phenomenex Gemini-C18 10 μm, gradient 5%→90% acetonitrile in water+0.3% NH4OH, 120 mL/min)