Dimethyl Sulfone → HCID 67997575, compound

HRID 1425973Notes

Reaction equation

HRID 1425973 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4](F)[CH:3]=1.[CH3:9][S:10]([CH3:13])(=[O:12])=[O:11]>>[Br:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([CH2:9][S:10]([CH3:13])(=[O:12])=[O:11])[CH:3]=1

Participants

3

Reactant 2

HCID 6213Dimethyl SulfoneHCID 27628514-Bromo-2-fluoropyridine

Product 1

HCID 67997575HCID 67997575, compoundYield 91%

Procedure

The title compound was prepared from 4-bromo-2-fluoro-pyridine and dimethylsulfone following a procedure analogous to that described in Step 1 for Intermediate 14. Yield: ca. 91% of theory (crude); LC (method 3): tR=2.01 min; Mass spectrum (ESI+): m/z=250/252 (Br) [M+H]+.

Sources & evidence

ORD record
ord-cd24551ba2ae47018b33835e2265f0ac
Source dataset
uspto-grants-2015_01
Patent number
US08933072B2

Reaction notes

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