反应详情

Following the method of Example 1, Step B, benzoyl isothiocyanate (1.47 g, 8.99 mmol) and 3-(benzyloxy)-5-bromopyrazin-2-amine (2.29 g, 8.18 mmol) were reacted in THF (30 mL) to provide 1-benzoyl-3-(3-(benzyloxy)-5-bromopyrazin-2-yl)thiourea (2.38 g, 66%) as a yellow powder. 1H NMR (CDCl3) δ 8.15 (bs, 1H), 7.91 (d, 2H), 7.66 (t, 1H), 7.53-7.57 (m, 4H), 7.36-7.44 (m, 3H), 5.55 (s, 2H). Mass spectrum (apci) m/z=202 (100), 443 (45), 445 (43) (M+H).