Hydrochloric Acid → HCID 67954200, compound

HRID 1426302Notes

Reaction equation

HRID 1426302 reaction equation
[CH3:1][N:2]([CH2:4][C:5]1[CH:6]=[C:7]([CH:22]=[C:23]([F:25])[CH:24]=1)[O:8][CH:9]1[CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH2:10]1)[CH3:3].[ClH:26].O1CCOCC1>C(Cl)Cl>[ClH:26].[ClH:26].[F:25][C:23]1[CH:24]=[C:5]([CH2:4][N:2]([CH3:3])[CH3:1])[CH:6]=[C:7]([O:8][CH:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[CH:22]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 69673293HCID 69673293, compound

Product 1

HCID 67954200HCID 67954200, compoundYield 87%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of tert-butyl 4-{3-[(dimethylamino)methyl]-5-fluorophenoxy}piperidine-1-carboxylate (180 mg, 0.51 mmol) in DCM (2.4 mL) was added 4.0M hydrogen chloride in dioxane (1.0 mL, 4.1 mmol). The reaction solution was stirred at room temperature for 6 hours. The solvent was removed to give the desired product as white solid (145 mg, 87%). LCMS (M+H)+: 253.1.

Workup

  1. customThe solvent was removed

Sources & evidence

ORD record
ord-bc07b495bd98480083198b1ac8b57eb3
Source dataset
uspto-grants-2015_01
Patent number
US08933085B2

Reaction notes

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