反应详情

To a solution of tert-butyl ({5-(2-cyanopyridin-3-yl)-1-[(2,6-difluorophenyl)sulfonyl]-1H-pyrrol-3-yl}methyl)methylcarbamate (213 mg) in ethyl acetate (2 mL) and 2-propanol (1 mL) was added 4 mol/L hydrogen chloride-ethyl acetate solution (3 mL), and the mixture was stirred at room temperature for 2 hr. The reaction mixture was concentrated under reduced pressure, and the residue was recrystallized from ethanol to give the title compound as a white solid (yield 160 mg, 86%).

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. customthe residue was recrystallized from ethanol