反应详情

温度

130 °C

3-(Benzyloxy)-4-ethoxy benzaldehyde described in Production Example 15-2 (14.5 g, 56.4 mmol) was dissolved in acetic acid (45 mL), then ammonium acetate (5.22 g, 67.7 mmol) and nitromethane (7.5 mL, 138 mmol) were added under nitrogen atmosphere at room temperature, and the mixture was heated and stirred at 130° C. for 2.5 hours. The mixture was cooled to room temperature and the precipitate was collected by filteration and washed with ethanol to quantitatively obtain the title compound.

1. temperaturethe mixture was heated
2. temperatureThe mixture was cooled to room temperature
3. customthe precipitate was collected by filteration
4. washwashed with ethanol