反应详情

Potassium carbonate (3.91 g, 28.3 mmol) and benzyl bromide (2.5 mL, 21.1 mmol) were added to a solution of 4-(difluoromethoxy)-3-hydroxybenzaldehyde described in Production Example 19-1 (2.66 g, 14.2 mmol) in acetonitrile (50 mL) at room temperature, and the mixture was stirred at room temperature for 3 hours. The reaction mixture was filtered and then the solvent was evaporated. The resultant residue was purified with silica gel column chromatography (n-heptane:ethyl acetate=9:1-3:2). The target fraction was concentrated under vacuum and then the title compound was quantitatively obtained.

1. filtrationThe reaction mixture was filtered
2. customthe solvent was evaporated
3. customThe resultant residue was purified with silica gel column chromatography (n-heptane:ethyl acetate=9:1-3:2)
4. concentrationThe target fraction was concentrated under vacuum