Nitromethane → HCID 86730354, compound

HRID 1427053Notes

Reaction equation

HRID 1427053 reaction equation
C([O-])(=O)C.[NH4+].[N+:6]([CH3:9])([O-:8])=[O:7].[CH2:10]([O:17][C:18]1[CH:19]=[C:20]([CH:23]=[CH:24][C:25]=1[O:26][CH2:27][CH2:28][CH2:29][O:30][CH3:31])[CH:21]=O)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>C(O)(=O)C>[CH2:10]([O:17][C:18]1[CH:19]=[C:20](/[CH:21]=[CH:9]/[N+:6]([O-:8])=[O:7])[CH:23]=[CH:24][C:25]=1[O:26][CH2:27][CH2:28][CH2:29][O:30][CH3:31])[C:11]1[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

Participants

5

Reactant 3

HCID 6375NitromethaneHCID 517165Ammonium AcetateHCID 86730353HCID 86730353, compound

Product 1

HCID 86730354HCID 86730354, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
130 °C

Procedure

Ammonium acetate (6.10 g, 79.1 mmol) and nitromethane (8.93 mL, 165 mmol) were added to a solution of 3-(benzyloxy)-4-(3-methoxypropoxy)benzaldehyde described in Production Example 32-2 (19.8 g, 65.9 mmol) in acetic acid (52.8 mL) under nitrogen atmosphere at room temperature. The liquid mixture was stirred under a thermal condition of 130° C. for 2 hours. The reaction liquid was allowed to stand to cool to room temperature, then the precipitate was collected by filteration and washed with ethanol to quantitatively obtain the title compound.

Workup

  1. customThe reaction liquid
  2. temperatureto cool to room temperature
  3. customthe precipitate was collected by filteration
  4. washwashed with ethanol

Sources & evidence

ORD record
ord-4aa1850610b842818bd47a3cfc642880
Source dataset
uspto-grants-2015_01
Patent number
US08933099B2

Reaction notes

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