反应详情

温度

130 °C

Ammonium acetate (6.10 g, 79.1 mmol) and nitromethane (8.93 mL, 165 mmol) were added to a solution of 3-(benzyloxy)-4-(3-methoxypropoxy)benzaldehyde described in Production Example 32-2 (19.8 g, 65.9 mmol) in acetic acid (52.8 mL) under nitrogen atmosphere at room temperature. The liquid mixture was stirred under a thermal condition of 130° C. for 2 hours. The reaction liquid was allowed to stand to cool to room temperature, then the precipitate was collected by filteration and washed with ethanol to quantitatively obtain the title compound.

1. customThe reaction liquid
2. temperatureto cool to room temperature
3. customthe precipitate was collected by filteration
4. washwashed with ethanol