Nitromethane → HCID 86730363, compound

HRID 1427062Notes

Reaction equation

HRID 1427062 reaction equation
[CH2:1]([O:8][C:9]1[CH:10]=[C:11]([CH:14]=[CH:15][C:16]=1[O:17][CH2:18][CH2:19][CH2:20][F:21])[CH:12]=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C([O-])(=O)C.[NH4+].[N+:27]([CH3:30])([O-:29])=[O:28]>C(O)(=O)C>[CH2:1]([O:8][C:9]1[CH:10]=[C:11](/[CH:12]=[CH:30]/[N+:27]([O-:29])=[O:28])[CH:14]=[CH:15][C:16]=1[O:17][CH2:18][CH2:19][CH2:20][F:21])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 6375NitromethaneHCID 517165Ammonium AcetateHCID 86730362HCID 86730362, compound

Product 1

HCID 86730363HCID 86730363, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
130 °C

Procedure

3-(Benzyloxy)-4-(3-fluoropropoxy)benzaldehyde described in Production Example 33-2 (6.14 g, 21.3 mmol) was dissolved in acetic acid (17.0 mL), then ammonium acetate (1.97 g, 25.6 mmol) and nitromethane (2.8 mL, 51.7 mmol) were added under nitrogen atmosphere at room temperature, and the mixture was heated and stirred at 130° C. for 2 hours. The mixture was cooled to mom temperature, then the precipitate was collected by filteration and washed with a small quantity of ethanol to quantitatively obtain the title compound.

Workup

  1. temperaturethe mixture was heated
  2. temperatureThe mixture was cooled to mom temperature
  3. customthe precipitate was collected by filteration
  4. washwashed with a small quantity of ethanol

Sources & evidence

ORD record
ord-5fc7593e18884ff3a8fbad1893d3ac8d
Source dataset
uspto-grants-2015_01
Patent number
US08933099B2

Reaction notes

Loading…