反应详情

温度

130 °C

3-(Benzyloxy)-4-(3-fluoropropoxy)benzaldehyde described in Production Example 33-2 (6.14 g, 21.3 mmol) was dissolved in acetic acid (17.0 mL), then ammonium acetate (1.97 g, 25.6 mmol) and nitromethane (2.8 mL, 51.7 mmol) were added under nitrogen atmosphere at room temperature, and the mixture was heated and stirred at 130° C. for 2 hours. The mixture was cooled to mom temperature, then the precipitate was collected by filteration and washed with a small quantity of ethanol to quantitatively obtain the title compound.

1. temperaturethe mixture was heated
2. temperatureThe mixture was cooled to mom temperature
3. customthe precipitate was collected by filteration
4. washwashed with a small quantity of ethanol