Triethylamine → HCID 59747697, compound

HRID 1427148Notes

Reaction equation

HRID 1427148 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[S:12][CH2:11][CH2:10][NH:9][CH2:8][C:7]=2[CH:13]=1.C(N(CC)CC)C.[Br:21][CH2:22][CH2:23][C:24](Cl)=[O:25]>C1COCC1>[Br:21][CH2:22][CH2:23][C:24]([N:9]1[CH2:8][C:7]2[CH:13]=[C:3]([O:2][CH3:1])[CH:4]=[CH:5][C:6]=2[S:12][CH2:11][CH2:10]1)=[O:25]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 84944Propanoyl chloride, 3-bromo-HCID 118056287-Methoxy-2,3,4,5-tetrahydro-1,4-benzothiazepine

Product 1

HCID 59747697HCID 59747697, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
0 °C

Procedure

To a stirred solution of 7-methoxy-2,3,4,5-tetrahydro-1,4-benzothiazepine (0.250 g) and triethyl amine (0.53 g) in THF (10 ml) at 0° C. was added dropwise 3-bromopropionic chloride (0.444 g). The resulting mixture was stirred at 0° C. for 1 hour and at room temperature overnight. After dilution with ethyl acetate, the organic phase was washed with saturated NaHCO3/H2O and H2O. After drying over sodium sulfate and filtration, removal of solvent gave to the product.

Workup

  1. washAfter dilution with ethyl acetate, the organic phase was washed with saturated NaHCO3/H2O and H2O
  2. dry with materialAfter drying over sodium sulfate and filtration, removal of solvent
  3. customgave to the product

Sources & evidence

ORD record
ord-1ef20826b8944e94930ecf346e5caf7b
Source dataset
uspto-grants-2015_01
Patent number
US08933129B2

Reaction notes

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