Dimethylformamide dimethyl acetal → HCID 86705039, compound

HRID 1427210Notes

Reaction equation

HRID 1427210 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([N+:12]([O-:14])=[O:13])[C:5]([CH3:11])=[C:6]([N+:8]([O-:10])=[O:9])[CH:7]=1.CO[CH:17](OC)[N:18]([CH3:20])[CH3:19]>CN(C)C=O>[F:1][C:2]1[CH:3]=[C:4]([N+:12]([O-:14])=[O:13])[C:5]([CH:11]=[CH:17][N:18]([CH3:20])[CH3:19])=[C:6]([N+:8]([O-:10])=[O:9])[CH:7]=1

Participants

4

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 184653725-Fluoro-2-methyl-1,3-dinitrobenzene

Product 1

HCID 86705039HCID 86705039, compoundYield 94%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
120 °C

Procedure

To a solution of 5-fluoro-2-methyl-1,3-dinitrobenzene (15 g, 0.075 mol) in N,N-dimethylformamide (300 mL) was added dimethylformamide dimethylacetal (89 g, 0.75 mol). The bright red reaction mixture was heated at 120° C. for 5 h, then concentrated in vacuo to provide 18 g crude product, which was used in the next step without further purification. LC/MS m/z=256.2 [M+H]+.

Workup

  1. customThe bright red reaction mixture
  2. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-62b6a284456b44b584058394e44eb75c
Source dataset
uspto-grants-2015_01
Patent number
US08933113B2

Reaction notes

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