Nitromethane → HCID 72709667, compound

HRID 1427693Notes

Reaction equation

HRID 1427693 reaction equation
[Br:1][C:2]1[CH:19]=[CH:18][CH:17]=[CH:16][C:3]=1[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:7](=[O:14])[C:6]1=[O:15].[N+:20]([CH3:23])([O-:22])=[O:21]>O>[Br:1][C:2]1[CH:19]=[CH:18][CH:17]=[CH:16][C:3]=1[CH2:4][N:5]1[C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[C:7]([OH:14])([CH2:23][N+:20]([O-:22])=[O:21])[C:6]1=[O:15]

Participants

4

Reactant 2

HCID 6375NitromethaneHCID 2232991HCID 2232991, compound

Product 1

HCID 72709667HCID 72709667, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
30 °C

Procedure

1-(2-bromobenzyl)indoline-2,3-dione (0.158 g) and nitromethane (0.15 ml) were added to water and the reaction mixture was vigorously stirred at a temperature of 30° C. for 30 hours. The obtained product was extracted with ethyl acetate and purified by silica gel column chromatography using ethyl acetate/hexane as eluents to afford pure product.

Workup

  1. extractionThe obtained product was extracted with ethyl acetate
  2. custompurified by silica gel column chromatography
  3. customto afford pure product

Sources & evidence

ORD record
ord-761473286cc749dba5342d8577259aff
Source dataset
uspto-grants-2015_01
Patent number
US08933248B2

Reaction notes

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