Nitromethane → HCID 72709671, compound

HRID 1427695Notes

Reaction equation

HRID 1427695 reaction equation
[Br:1][C:2]1[CH:20]=[CH:19][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([Cl:16])=[CH:13][CH:14]=3)[C:9](=[O:17])[C:8]2=[O:18])=[CH:4][CH:3]=1.[N+:21]([CH3:24])([O-:23])=[O:22]>O>[Br:1][C:2]1[CH:20]=[CH:19][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([Cl:16])=[CH:13][CH:14]=3)[C:9]([OH:17])([CH2:24][N+:21]([O-:23])=[O:22])[C:8]2=[O:18])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 6375NitromethaneHCID 29299283HCID 29299283, compound

Product 1

HCID 72709671HCID 72709671, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
30 °C

Procedure

1-(4-bromobenzyl)-5-chloroindoline-2,3-dione (0.175 g) and nitromethane (0.15 ml) were added to water and the reaction mixture was vigorously stirred at a temperature of 30° C. for 24 hours. The obtained product was extracted with ethyl acetate and purified by silica gel column chromatography using ethyl acetate/hexane as eluents to afford pure product.

Workup

  1. extractionThe obtained product was extracted with ethyl acetate
  2. custompurified by silica gel column chromatography
  3. customto afford pure product

Sources & evidence

ORD record
ord-f40c312eb78e454da8a0f532f7a9a409
Source dataset
uspto-grants-2015_01
Patent number
US08933248B2

Reaction notes

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