反应详情

A solution of methyllithium in ether (1 M, 4.8 ml) was added to a solution of 3,5-dibromopyridin-4-ol (1200 mg) in THF (10 ml) at −78° C., and the mixture was stirred for 30 minutes. A solution of n-butyllithium in hexane (1.65 M, 6.0 ml) was added at −78° C., and the mixture was stirred for one hour. Dry ice was added at −78° C. and the mixture was stirred at 0° C. for 20 minutes, followed by addition of a 4 N aqueous hydrochloric acid solution. The precipitated solid was collected by filtration and washed with water to give a mixture of the title compound and 3,5-dibromopyridin-4-ol.

1. stirringthe mixture was stirred for one hour
2. stirringthe mixture was stirred at 0° C. for 20 minutes
3. filtrationThe precipitated solid was collected by filtration
4. washwashed with water
5. customto give