Hydrochloric Acid → HCID 86700081, compound

HRID 1428128Notes

Reaction equation

HRID 1428128 reaction equation
C(#N)C.[ClH:4].[NH2:5][C:6]1[C:11]([C:12]2[CH:17]=[CH:16][C:15]([NH:18][C:19]([C:21]3[C:26](=[O:27])[C:25]([C:28]4[CH:33]=[CH:32][C:31]([F:34])=[CH:30][CH:29]=4)=[CH:24][N:23]([CH2:35][C:36]([F:39])([F:38])[F:37])[CH:22]=3)=[O:20])=[CH:14][CH:13]=2)=[CH:10][C:9]([C:40]2[CH:45]=[CH:44][C:43]([O:46][CH3:47])=[C:42]([O:48][CH3:49])[CH:41]=2)=[CH:8][N:7]=1>O>[ClH:4].[NH2:5][C:6]1[C:11]([C:12]2[CH:13]=[CH:14][C:15]([NH:18][C:19]([C:21]3[C:26](=[O:27])[C:25]([C:28]4[CH:29]=[CH:30][C:31]([F:34])=[CH:32][CH:33]=4)=[CH:24][N:23]([CH2:35][C:36]([F:37])([F:38])[F:39])[CH:22]=3)=[O:20])=[CH:16][CH:17]=2)=[CH:10][C:9]([C:40]2[CH:45]=[CH:44][C:43]([O:46][CH3:47])=[C:42]([O:48][CH3:49])[CH:41]=2)=[CH:8][N:7]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 6342AcetonitrileHCID 71698834HCID 71698834, compound

Product 1

HCID 86700081HCID 86700081, compoundYield 60%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
40 °C

Procedure

Acetonitrile (383 μl), a 5.788 mol/L aqueous hydrochloric acid solution (5.67 μl, 1.05 eq.) and water (4.15 μl) were added to N-{4-[2-amino-5-(3,4-dimethoxyphenyl)pyridin-3-yl]phenyl}-5-(4-fluorophenyl)-4-oxo-1-(2,2,2-trifluoroethyl)-1,4-dihydropyridine-3-carboxamide (19.64 mg, 31.75 μmol) at room temperature. After stirring at 40° C. for about 24 hours, the precipitated solid was collected by filtration. The solid was then dried at room temperature to give the title compound (12.42 mg). Yield: 60%.

Workup

  1. filtrationthe precipitated solid was collected by filtration
  2. customThe solid was then dried at room temperature

Sources & evidence

ORD record
ord-128f1d0a736d465982253754b582f509
Source dataset
uspto-grants-2015_01
Patent number
US08933103B2

Reaction notes

Loading…