Hydrochloric Acid → HCID 86700081, compound

HRID 1428135Notes

Reaction equation

HRID 1428135 reaction equation
C(O)C.[ClH:4].[NH2:5][C:6]1[C:11]([C:12]2[CH:17]=[CH:16][C:15]([NH:18][C:19]([C:21]3[C:26](=[O:27])[C:25]([C:28]4[CH:33]=[CH:32][C:31]([F:34])=[CH:30][CH:29]=4)=[CH:24][N:23]([CH2:35][C:36]([F:39])([F:38])[F:37])[CH:22]=3)=[O:20])=[CH:14][CH:13]=2)=[CH:10][C:9]([C:40]2[CH:45]=[CH:44][C:43]([O:46][CH3:47])=[C:42]([O:48][CH3:49])[CH:41]=2)=[CH:8][N:7]=1>O>[ClH:4].[NH2:5][C:6]1[C:11]([C:12]2[CH:13]=[CH:14][C:15]([NH:18][C:19]([C:21]3[C:26](=[O:27])[C:25]([C:28]4[CH:29]=[CH:30][C:31]([F:34])=[CH:32][CH:33]=4)=[CH:24][N:23]([CH2:35][C:36]([F:37])([F:38])[F:39])[CH:22]=3)=[O:20])=[CH:16][CH:17]=2)=[CH:10][C:9]([C:40]2[CH:45]=[CH:44][C:43]([O:46][CH3:47])=[C:42]([O:48][CH3:49])[CH:41]=2)=[CH:8][N:7]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 71698834HCID 71698834, compound

Product 1

HCID 86700081HCID 86700081, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Conditions

Temperature
40 °C

Procedure

Ethanol (14.8 ml), concentrated hydrochloric acid (as 12 mol/L) (219 μl, 1.05 eq.) and water (6 μl) were added to N-{4-[2-amino-5-(3,4-dimethoxyphenyl)pyridin-3-yl]phenyl}-5-(4-fluorophenyl)-4-oxo-1-(2,2,2-trifluoroethyl)-1,4-dihydropyridine-3-carboxamide (1.50 g, 2.43 mmol) at room temperature. The mixture was stirred at 40° C. for about 11 hours and then at room temperature for one hour, and the precipitated solid was collected by filtration. The solid was then dried under reduced pressure at room temperature for three hours to give the title compound (1.54 g). Yield: 97%.

Workup

  1. waitat room temperature for one hour
  2. filtrationthe precipitated solid was collected by filtration
  3. customThe solid was then dried under reduced pressure at room temperature for three hours

Sources & evidence

ORD record
ord-8a396aac49bb447380c1c4a86f525505
Source dataset
uspto-grants-2015_01
Patent number
US08933103B2

Reaction notes

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