HCID 46941732, compound → HCID 86682824, compound

HRID 1428177Notes

Reaction equation

HRID 1428177 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[C:13]([CH2:14][OH:15])=[CH:12][N:11]=[CH:10][N:9]=2)=[CH:4][CH:3]=1>[O-2].[O-2].[Mn+4].O1CCCC1>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:13]([CH:14]=[O:15])=[CH:12][N:11]=[CH:10][N:9]=2)=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 46941732HCID 46941732, compound

Product 1

HCID 86682824HCID 86682824, compoundYield 75.7%

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 8028TetrahydrofuranSolvent

Procedure

A mixture of [4-(4-fluorophenyl)pyrimidin-5-yl]methanol (4.8 g), manganese dioxide (28 g) and tetrahydrofuran (300 mL) was stirred overnight at room temperature. The reaction mixture was filtered, and the filtrate was concentrated under reduced pressure to give the title compound (3.6 g).

Workup

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe filtrate was concentrated under reduced pressure

Sources & evidence

ORD record
ord-3737b5e11db0448bbc0f0aae3b258209
Source dataset
uspto-grants-2015_01
Patent number
US08937055B2

Reaction notes

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