Benzene → 4-Chlorobutyrophenone

HRID 1428451Notes

Reaction equation

HRID 1428451 reaction equation
[CH:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Cl:7][CH2:8][CH2:9][CH2:10][C:11](Cl)=[O:12].[Cl-].[Al+3].[Cl-].[Cl-]>ClCCl>[Cl:7][CH2:8][CH2:9][CH2:10][C:11]([C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)=[O:12]

Participants

5

Reactant 3

HCID 241BenzeneHCID 783704-Chlorobutyryl chlorideHCID 6451240Aluminum(III) Chloride

Product 1

HCID 2535334-ChlorobutyrophenoneYield 881%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Benzene (0.5 mg), 4-chlorobutyryl chloride (141 mg), and aluminium chloride (170 mg) were reacted in dichloromethane (1.5 mL) at from 0° C. to room temperature for 4 hours. The resultant was treated in the same manner as described in Example 1 to obtain the title compound (10.3 mg).

Workup

  1. additionThe resultant was treated in the same manner

Sources & evidence

ORD record
ord-e5551fd393ac428cb99cb8742d23c706
Source dataset
uspto-grants-2015_01
Patent number
US08937091B2

Reaction notes

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