反应详情

温度

150 °C

To a solution of compound D2 (1.2 g, 4.15 mmol) in THF (12 ml) was added hydrazine monohydrate (0.416 g, 8.301 mmol). The reaction mixture was heated at 150° C. under microwave irradiation for 1 min. After cooling, additional hydrazine monohydrate (1 eq) was added to the reaction mixture, which was then heated at 150° C. under microwave irradiation for 0.5 min. After cooling, the reaction mixture was concentrated in vacuo. The residue thus obtained was triturated with Et2O to yield intermediate compound D3 (0.95 g, 95%).

1. temperatureAfter cooling
2. temperaturewas then heated at 150° C. under microwave irradiation for 0.5 min
3. temperatureAfter cooling
4. concentrationthe reaction mixture was concentrated in vacuo
5. customThe residue thus obtained
6. customwas triturated with Et2O