反应详情

To a stirred solution of methyl 2-(3-chloro-4-cyanophenyl)propanoate (642 mg, 2.87 mmol) in co-solvent with tetrahydrofuran and water (1:1) were added sodium hydroxide (287 mg, 7.175 mmol). The reaction mixture was stirred for 15 h at room temperature, then acidified to pH 3-4 with acetic acid. The residue dissolved in ethyl acetate and washed with water and brine. The organic layer was dried over magnesium sulfate and filtered. The filtrate removed in vacuo. The crude was purified by column chromatography. 2-(3-Chloro-4-cyanophenyl)propanoic acid (665 mg) was obtained as 99% yield.

1. washwashed with water and brine
2. dry with materialThe organic layer was dried over magnesium sulfate
3. filtrationfiltered
4. customThe filtrate removed in vacuo
5. customThe crude was purified by column chromatography