反应详情

To a stirred solution of ethyl 2-(4-cyanophenyl)acetate (0.8 g, 4.101 mmol) in anhydrous dimethylformamide were added 60% sodium hydride (180 mg, 4.511 mol) and Iodo methane were added after 10 min with an ice bath. The reaction mixture was stirred for 1 h hours, quenched with water and extracted with ethylacetate which is washed with water and brine. The organic layer was dried over magnesium sulfate and filtered. The filterate was concentrated under reduced pressure. The residue was purified by column chromatography. Ethyl 2-(4-cyanophenyl)propanoate (453 mg) was obtained as 48%

1. additionwere added after 10 min with an ice bath
2. customquenched with water
3. extractionextracted with ethylacetate which
4. washis washed with water and brine
5. dry with materialThe organic layer was dried over magnesium sulfate
6. filtrationfiltered
7. concentrationThe filterate was concentrated under reduced pressure
8. customThe residue was purified by column chromatography