反应详情

温度

60 °C

10.8 g piperazine-1-carboxylic acid tert-butyl ester was added to 8.3 g 4-chloro-6-methoxy-pyrimidine and 16 mL triethylamine in 40 mL DMF. The reaction was stirred over night at 60° C. The mixture was diluted with water and extracted with ethyl acetate. The organic layer was dried with magnesium sulfate and evaporated. The residue was purified chromatography on silica gel (petrolether/ethyl acetate: 8/2) to yield 9.8 g of the desired compound.

1. extractionextracted with ethyl acetate
2. dry with materialThe organic layer was dried with magnesium sulfate
3. customevaporated
4. customThe residue was purified chromatography on silica gel (petrolether/ethyl acetate: 8/2)