反应详情

Compound 2d (200 mg, 0.305 mmol) was dissolved in DCM (10 ml). EDAC (70 mg, 0.366 mmol) was added and the reaction mixture was stirred at RT for 30 min. Cyclopropanesulfonic amide (41 mg, 0.336 mmol) and DBU (96 μl, 0.641 mmol) were added and the reaction was stirred at RT for 72 h. 5% Citric acid was added and the organic layer was separated and washed with brine, dried, filtered and evaporated. This material was used directly in the following step without further purification.

1. stirringthe reaction was stirred at RT for 72 h
2. customthe organic layer was separated
3. washwashed with brine
4. customdried
5. filtrationfiltered
6. customevaporated
7. customThis material was used directly in the following step without further purification