HCID 68590505, compound → HCID 68590782, compound

HRID 1429168Notes

Reaction equation

HRID 1429168 reaction equation
[CH2:1]([O:3][C:4]([C:6]1([NH:11][C:12]([CH:14]2[CH2:18][CH:17]([O:19][C:20]3[CH:25]=[C:24]([C:26]4[CH:31]=[CH:30][C:29]([O:32][CH3:33])=[CH:28][CH:27]=4)[N:23]=[C:22]([O:34][CH3:35])[N:21]=3)[CH2:16][CH:15]2[C:36](=[O:45])[N:37]([CH2:39][CH2:40][CH2:41][CH2:42][CH:43]=[CH2:44])[CH3:38])=[O:13])[CH2:8][CH:7]1C=C)=[O:5])[CH3:2]>CC1C=C(C)C(N2C(=[Ru](Cl)(Cl)=CC3C=CC=CC=3OC(C)C)N(C3C(C)=CC(C)=CC=3C)CC2)=C(C)C=1.ClCCCl>[CH2:1]([O:3][C:4]([C:6]12[CH2:7][CH:8]1[CH:44]=[CH:43][CH2:42][CH2:41][CH2:40][CH2:39][N:37]([CH3:38])[C:36](=[O:45])[CH:15]1[CH:14]([CH2:18][CH:17]([O:19][C:20]3[CH:25]=[C:24]([C:26]4[CH:27]=[CH:28][C:29]([O:32][CH3:33])=[CH:30][CH:31]=4)[N:23]=[C:22]([O:34][CH3:35])[N:21]=3)[CH2:16]1)[C:12](=[O:13])[NH:11]2)=[O:5])[CH3:2]

Participants

4

Reactant 1

HCID 68590505HCID 68590505, compound

Product 1

HCID 68590782HCID 68590782, compoundYield 62%

Reagents, catalysts & solvents 2

HCID 11763533(1,3-Bis(2,4,6-trimethylphenyl)imidazolidin-2-ylidene)(dichloro)((2-((propan-2-yl)oxy)phenyl)methylidene)rutheniumCatalystHCID 111,2-DichloroethaneSolvent

Procedure

The diolefin 16d (0.95 g, 1.53 mmol) was reacted with Hoveyda Grubbs 2nd generation catalyst (140 mg) in DCE (900 ml) according to the procedure described in Example 13 step d which gave the crude title compound, (560 mg, 62%), (M+H)+565.

Sources & evidence

ORD record
ord-e2341ad9af954a8fa1610980d026cd72
Source dataset
uspto-grants-2015_01
Patent number
US08937080B2

Reaction notes

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