HCID 68590874, compound → HCID 68590234, compound

HRID 1429174Notes

Reaction equation

HRID 1429174 reaction equation
[CH2:1]([O:3][C:4]([C:6]1([NH:11][C:12]([CH:14]2[CH2:18][CH:17]([O:19][C:20]3[CH:25]=[C:24]([C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=4)[N:23]=[C:22]([C:32]4[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=4)[N:21]=3)[CH2:16][CH:15]2[C:38](=[O:47])[N:39]([CH2:41][CH2:42][CH2:43][CH2:44]C=C)[CH3:40])=[O:13])[CH2:8][CH:7]1[CH:9]=[CH2:10])=[O:5])[CH3:2]>CC1C=C(C)C(N2C(=[Ru](Cl)(Cl)=CC3C=CC=CC=3OC(C)C)N(C3C(C)=CC(C)=CC=3C)CC2)=C(C)C=1.ClCCCl>[CH2:1]([O:3][C:4]([C:6]12[CH2:8][CH:7]1[CH:9]=[CH:10][CH2:44][CH2:43][CH2:42][CH2:41][N:39]([CH3:40])[C:38](=[O:47])[CH:15]1[CH:14]([CH2:18][CH:17]([O:19][C:20]3[CH:25]=[C:24]([C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=4)[N:23]=[C:22]([C:32]4[CH:33]=[CH:34][CH:35]=[CH:36][CH:37]=4)[N:21]=3)[CH2:16]1)[C:12](=[O:13])[NH:11]2)=[O:5])[CH3:2]

Participants

4

Reactant 1

HCID 68590874HCID 68590874, compound

Product 1

HCID 68590234HCID 68590234, compoundYield 76.1%

Reagents, catalysts & solvents 2

HCID 11763533(1,3-Bis(2,4,6-trimethylphenyl)imidazolidin-2-ylidene)(dichloro)((2-((propan-2-yl)oxy)phenyl)methylidene)rutheniumCatalystHCID 111,2-DichloroethaneSolvent

Procedure

The diolefin 17d (0.95 g, 1.49 mmol) was reacted with Hoveyda Grubbs 2nd generation catalyst (135 mg) in DCE (900 ml) according to the procedure described in Example 13 step d, which gave the title compound, (0.69 g, 76%), (M+H)+609.

Sources & evidence

ORD record
ord-8f2c788c443a472682d05458491e05d6
Source dataset
uspto-grants-2015_01
Patent number
US08937080B2

Reaction notes

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