Trifluoroacetic acid → HCID 68590687, compound

HRID 1429179Notes

Reaction equation

HRID 1429179 reaction equation
C([O:5][C:6]([CH:8]1[CH2:12][CH:11]([O:13][C:14]2[CH:19]=[C:18]([O:20][CH3:21])[N:17]=[C:16]([O:22][CH3:23])[N:15]=2)[CH2:10][CH:9]1[C:24](=[O:36])[NH:25][C:26]1([C:31]([O:33][CH2:34][CH3:35])=[O:32])[CH2:28][CH:27]1[CH:29]=[CH2:30])=[O:7])(C)(C)C.C([SiH](CC)CC)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:23][O:22][C:16]1[N:15]=[C:14]([O:13][CH:11]2[CH2:12][CH:8]([C:6]([OH:7])=[O:5])[CH:9]([C:24](=[O:36])[NH:25][C:26]3([C:31]([O:33][CH2:34][CH3:35])=[O:32])[CH2:28][CH:27]3[CH:29]=[CH2:30])[CH2:10]2)[CH:19]=[C:18]([O:20][CH3:21])[N:17]=1

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 12052TriethylsilaneHCID 68590570HCID 68590570, compound

Product 1

HCID 68590687HCID 68590687, compoundYield 100.9%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Compound 18c (0.92 g, 1.83 mmol) was treated with triethylsilane (0.58 g, 5.0 mmol) and TFA (25 ml) in DCM (25 ml) according to the procedure described in Example 13 step b which gave the title compound, (0.83 g), (M+H)+450.

Sources & evidence

ORD record
ord-3542e9559b934854970a03daa4b02968
Source dataset
uspto-grants-2015_01
Patent number
US08937080B2

Reaction notes

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