Aluminium lithium hydride → HCID 68532835, compound

HRID 1429300Notes

Reaction equation

HRID 1429300 reaction equation
[CH3:1][O:2][CH2:3][C:4]1[CH:8]=[C:7]([CH2:9][O:10][CH3:11])[N:6]([CH2:12][CH2:13][N:14]([CH2:21][CH2:22][N:23]2[C:27]([CH2:28][O:29][CH3:30])=[CH:26][C:25]([CH2:31][O:32][CH3:33])=[N:24]2)[CH2:15][C:16](OCC)=[O:17])[N:5]=1.[H-].[H-].[H-].[H-].[Li+].[Al+3]>C1COCC1>[CH3:1][O:2][CH2:3][C:4]1[CH:8]=[C:7]([CH2:9][O:10][CH3:11])[N:6]([CH2:12][CH2:13][N:14]([CH2:21][CH2:22][N:23]2[C:27]([CH2:28][O:29][CH3:30])=[CH:26][C:25]([CH2:31][O:32][CH3:33])=[N:24]2)[CH2:15][CH2:16][OH:17])[N:5]=1

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 68525508HCID 68525508, compound

Product 1

HCID 68532835HCID 68532835, compoundYield 60%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

This compound has been obtained by reacting a solution of ethyl 2-(bis(2-(3,5-bis(methoxymethyl)-1H-pyrazol-1-yl)ethyl)amino)acetate (280 mg; 0.6 mmol) in dry THF (10 mL) with LiAlH4. The title compound was isolated following the same methodology above described for the synthesis of other (hydroxymethyl)pyrazoles (see example 6). Yield: 60% (170 mg, 0.4 mmol).

Workup

  1. customThis compound has been obtained

Sources & evidence

ORD record
ord-7dbb0f4d6b0b4525a7af253cf134668a
Source dataset
uspto-grants-2015_01
Patent number
US08940273B2

Reaction notes

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