Hydrochloric Acid → HCID 67382367, compound

HRID 1429350Notes

Reaction equation

HRID 1429350 reaction equation
C(OC([NH:8][CH:9]([CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[CH2:10][O:11][CH2:12][C:13]1[CH:21]=[CH:20][CH:19]=[CH:18][C:14]=1[C:15]([OH:17])=[O:16])=O)(C)(C)C.[ClH:29]>O1CCOCC1>[ClH:29].[NH2:8][CH:9]([CH2:22][C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1)[CH2:10][O:11][CH2:12][C:13]1[CH:21]=[CH:20][CH:19]=[CH:18][C:14]=1[C:15]([OH:17])=[O:16]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 67417383HCID 67417383, compound

Product 1

HCID 67382367HCID 67382367, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Compound 1b (34.7 g, 90 mmol) was treated with HCl (g) in dioxane (700 mL) at rt overnight. Concentrated in vacuo gave the hydrochloride salt of compound 1c which was used for next step without any further purification (28.3 g, 98% yield). MS (ESI+): 286 [M+1]+.

Workup

  1. concentrationConcentrated in vacuo

Sources & evidence

ORD record
ord-c5ab2bb812d24357a417df158ddf4a36
Source dataset
uspto-grants-2015_01
Patent number
US08940722B2

Reaction notes

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