Trifluoroacetic acid → 6-Bromo-2-(piperidin-4-yloxy)thiazolo[4,5-b]pyridine

HRID 1429538Notes

Reaction equation

HRID 1429538 reaction equation
[Br:1][C:2]1[CH:3]=[C:4]2[S:10][C:9]([O:11][CH:12]3[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]3)=[N:8][C:5]2=[N:6][CH:7]=1.C(O)(C(F)(F)F)=O.BrC1C=CC2N=C(OC3CCNCC3)SC=2C=1>>[Br:1][C:2]1[CH:3]=[C:4]2[S:10][C:9]([O:11][CH:12]3[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]3)=[N:8][C:5]2=[N:6][CH:7]=1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 674668246-Bromo-2-(piperidin-4-yloxy)-benzothiazoleHCID 68208481tert-Butyl 4-(6-bromothiazolo[4,5-b]pyridin-2-yloxy)piperidine-1-carboxylate

Product 1

HCID 674627896-Bromo-2-(piperidin-4-yloxy)thiazolo[4,5-b]pyridine

Procedure

Compound 21C was prepared from Compound 21B and TFA in a similar manner to the procedure described for Compound 1B in Example 1. LC/MS (m/z)=314 (M+H)+.

Sources & evidence

ORD record
ord-f0817a01803f4defba993a9b685c8547
Source dataset
uspto-grants-2015_01
Patent number
US08940716B2

Reaction notes

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