反应详情

A mixture of 2-(1-bromopropyl)-3-iodo-6-methyl-4H-pyrido[1,2-a]pyrimidin-4-one (4.50 g, 11.0 mmol) and sodium azide (3.59 g, 55.3 mmol) in DMF was stirred at room temperature for 2 h. After diluting with ethyl acetate, the mixture was washed with water, brine, dried over sodium sulfate, and evaporated under reduced pressure to provide the crude product, which was used directly in next step (3.35 g, 82.1%). LCMS calculated for C12H13IN5O (M+H)+: m/z=370.0. Found: 370.2.

1. washthe mixture was washed with water, brine
2. dry with materialdried over sodium sulfate
3. customevaporated under reduced pressure