N-[5-(2-tert-butyl-pyridin-4-yl)-4-methyl-thiazol-2-yl]acetamide → 5-(2-Tert-butylpyridin-4-yl)-4-methylthiazol-2-amine

HRID 1430110Notes

Reaction equation

HRID 1430110 reaction equation
[CH3:1][C:2]1[N:3]=[C:4]([NH:17]C(=O)C)[S:5][C:6]=1[C:7]1[CH:12]=[CH:11][N:10]=[C:9]([C:13]([CH3:16])([CH3:15])[CH3:14])[CH:8]=1>C(O)C.Cl>[NH2:17][C:4]1[S:5][C:6]([C:7]2[CH:12]=[CH:11][N:10]=[C:9]([C:13]([CH3:16])([CH3:15])[CH3:14])[CH:8]=2)=[C:2]([CH3:1])[N:3]=1

Participants

4

Reactant 1

HCID 59293656N-[5-(2-tert-butyl-pyridin-4-yl)-4-methyl-thiazol-2-yl]acetamide

Product 1

HCID 574170735-(2-Tert-butylpyridin-4-yl)-4-methylthiazol-2-amine

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 702EthanolSolvent

Procedure

N-[4-methyl-5-(2-tert-butyl-4-pyridyl)-1,3-thiazol-2-yl]acetamide (90 mg) in ethanol (4.5 ml) and 6N hydrochloric acid (0.5 ml) is heated in a Emrys Optimiser personal chemistry microwave at 100° C. for 90 minutes. Cooling of the reaction mixture and filtration gives the title compound.

Workup

  1. temperatureCooling of the reaction mixture and filtration

Sources & evidence

ORD record
ord-c2b8cf43546a40b4bdf4c781d8abda8d
Source dataset
uspto-grants-2015_01
Patent number
US08940771B2

Reaction notes

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