Hydrochloric Acid → HCID 972473, compound

HRID 1430144Notes

Reaction equation

HRID 1430144 reaction equation
[CH3:1][C:2]1[N:3]=[C:4]([NH:19]C(=O)C)[S:5][C:6]=1[C:7]1[N:8]=[C:9]([NH:12][C:13]2[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=2)[S:10][CH:11]=1.Cl.C([O-])(O)=O.[Na+]>C(O)C>[CH3:1][C:2]1[N:3]=[C:4]([NH2:19])[S:5][C:6]=1[C:7]1[N:8]=[C:9]([NH:12][C:13]2[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=2)[S:10][CH:11]=1

Participants

5

Reactant 3

HCID 313Hydrochloric Acid2×HCID 516892Sodium BicarbonateHCID 11186583HCID 11186583, compound

Product 1

HCID 972473HCID 972473, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

N-[4′-Methyl-2-(pyridin-3-ylamino)-[4,5′]bithiazolyl-2′-yl]-acetamide (0.9 g) is refluxed in a mixture of ethanol (30 ml) and concentrated hydrochloric acid (3 ml) for 18 hours then additional hydrochloric acid is added (1.5 ml). After a further 24 hours at reflux the reaction mixture is cooled and the pH adjusted to 8-9 by the addition of 5% aqueous NaHCO3. The title compound is collected by filtration, washed with water and dried to give a light brown solid.

Workup

  1. temperatureAfter a further 24 hours at reflux the reaction mixture
  2. temperatureis cooled
  3. filtrationThe title compound is collected by filtration
  4. washwashed with water
  5. customdried
  6. customto give a light brown solid

Sources & evidence

ORD record
ord-104dc6f0e7164eebbdbfc3cd76616139
Source dataset
uspto-grants-2015_01
Patent number
US08940771B2

Reaction notes

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