Triethylamine → HCID 86681298, compound

HRID 1430231Notes

Reaction equation

HRID 1430231 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][NH:5][CH:6]=1.Br[CH:8]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.C(N(CC)CC)C>O1CCCC1>[CH:8]([N:4]1[CH:3]=[C:2]([Br:1])[CH:6]=[N:5]1)([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 163754-BromopyrazoleHCID 236603Bromodiphenylmethane

Product 1

HCID 86681298HCID 86681298, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 4-bromo-1H-pyrazole (0.294 g), (bromomethylene)dibenzene (0.494 g) and triethylamine (0.418 mL) in tetrahydrofuran (5 mL) was stirred at 60° C. for 24 hours. The reaction mixture was concentrated and purified by chromatography on silica gel using 0-20% ethyl acetate/hexanes as eluent to provide the title compound.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. custompurified by chromatography on silica gel using 0-20% ethyl acetate/hexanes as eluent

Sources & evidence

ORD record
ord-79bb35635df44a26ad9b9e0b7c1bb37d
Source dataset
uspto-grants-2015_01
Patent number
US08940737B2

Reaction notes

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