Hydrochloric Acid → HCID 89498001, compound

HRID 1430234Notes

Reaction equation

HRID 1430234 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][N:5]([CH:7]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:8][CH:9](OC)[O:10]C)[CH:6]=1.Cl>O1CCCC1>[Br:1][C:2]1[CH:3]=[N:4][N:5]([CH:7]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:8][CH:9]=[O:10])[CH:6]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 89498369HCID 89498369, compound

Product 1

HCID 89498001HCID 89498001, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of EXAMPLE 77B (0.34 g) and hydrochloric acid (2 mL) in tetrahydrofuran (3.5 mL) was stirred at room temperature for 16 hours. The reaction mixture was concentrated, redissolved in dichloromethane, dried over magnesium sulfate, filtered, and used in the next step without purification.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. dissolutionredissolved in dichloromethane
  3. dry with materialdried over magnesium sulfate
  4. filtrationfiltered
  5. customused in the next step without purification

Sources & evidence

ORD record
ord-aeb1f1a2f9434ae8ae6cfd0d615c4eaf
Source dataset
uspto-grants-2015_01
Patent number
US08940737B2

Reaction notes

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