Hydrochloric Acid → HCID 23534457, compound

HRID 1430320Notes

Reaction equation

HRID 1430320 reaction equation
[CH:1]1([S:7](Cl)(=[O:9])=[O:8])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:11][NH2:12].Cl>>[CH3:11][NH:12][S:7]([CH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1)(=[O:9])=[O:8]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 6329MethylamineHCID 237554Cyclohexanesulfonyl chloride

Product 1

HCID 23534457HCID 23534457, compound

Procedure

Cyclohexanesulfonyl chloride (500 mg) was added to methylamine (12.3 mL, 2M solution in tetrahydrofuran) and the reaction mixture was stirred at room temperature for one hour. The solution was added to 1M aqueous HCl and extracted with ethyl acetate. The extract was washed with brine and dried over anhydrous sodium sulfate. After filtration, the solvent was removed under vacuum to yield the product.

Workup

  1. extractionextracted with ethyl acetate
  2. washThe extract was washed with brine
  3. dry with materialdried over anhydrous sodium sulfate
  4. filtrationAfter filtration
  5. customthe solvent was removed under vacuum
  6. customto yield the product

Sources & evidence

ORD record
ord-5401b577aac44e61a5d52001d3a8cc5e
Source dataset
uspto-grants-2015_01
Patent number
US08940737B2

Reaction notes

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