反应详情

Methyl 3-(bis(tert-butoxycarbonyl)amino)-5-bromo-4-chlorobenzoate (3.06 g, 6.58 mmol) was dissolved in a solution of TFA (1.015 ml, 13.17 mmol) in CH2Cl2 (32.9 ml). The reaction was stirred at rt for 45 min, and then sat. NaHCO3 solution was added. The reaction mixture was diluted with a little more CH2Cl2 and washed 2× with sat. NaHCO3 to remove any residual TFA. The organic layer was dried over Na2SO4, filtered, and concentrated to provide methyl 3-bromo-5-(tert-butoxycarbonylamino)-4-chlorobenzoate (2.33 g) as a cream solid.

1. washwashed 2× with sat. NaHCO3
2. customto remove any residual TFA
3. dry with materialThe organic layer was dried over Na2SO4
4. filtrationfiltered
5. concentrationconcentrated