Pyridine → HCID 67507786, compound

HRID 1431234Notes

Reaction equation

HRID 1431234 reaction equation
[F:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.N1C=CC=CC=1.[CH3:15][CH:16]([C:22](OCC)=[O:23])[C:17]([O:19][CH2:20][CH3:21])=[O:18]>>[F:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:22](=[O:23])[CH:16]([CH3:15])[C:17]([O:19][CH2:20][CH3:21])=[O:18])=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 1049PyridineHCID 97314-FluoroanilineHCID 11857Diethyl methylmalonate

Product 1

HCID 67507786HCID 67507786, compound

Procedure

Prepared according to general Procedure A using 4-fluoroaniline (18 g, 162 mmol), pyridine (13 mL, 162 mmol) and diethyl methylmalonate (28 mL, 162 mmol). After purification ethyl 3-(4-fluorophenylamino)-2-methyl-3-oxopropanoate was obtained. Mass Spectrum (ESI) m/e=240.1 (M+1).

Workup

  1. customPrepared
  2. customAfter purification ethyl 3-(4-fluorophenylamino)-2-methyl-3-oxopropanoate
  3. customwas obtained

Sources & evidence

ORD record
ord-eaef0a7dbaea42299548e8fac8519af7
Source dataset
uspto-grants-2015_01
Patent number
US08940724B2

Reaction notes

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