Sodium Hydroxide → HCID 67508161, compound

HRID 1431235Notes

Reaction equation

HRID 1431235 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:17])[CH:10]([CH3:16])[C:11]([O:13]CC)=[O:12])=[CH:4][CH:3]=1.[OH-].[Na+]>C1COCC1>[F:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9](=[O:17])[CH:10]([CH3:16])[C:11]([OH:13])=[O:12])=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 67507786HCID 67507786, compound

Product 1

HCID 67508161HCID 67508161, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared according to general Procedure B using ethyl 3-(4-fluorophenylamino)-2-methyl-3-oxopropanoate (20.0 g, 84 mmol) and NaOH (4.3 g, 81.5 mmol) in THF (50 mL). After purification 3-(4-fluorophenylamino)-2-methyl-3-oxopropanoic acid was obtained as a white solid. Mass Spectrum (ESI) m/e=212.2 (M+1).

Workup

  1. customPrepared
  2. customAfter purification 3-(4-fluorophenylamino)-2-methyl-3-oxopropanoic acid
  3. customwas obtained as a white solid

Sources & evidence

ORD record
ord-dce9b91b62934b6bb4f12cd1591c2e8d
Source dataset
uspto-grants-2015_01
Patent number
US08940724B2

Reaction notes

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