Phosphorus oxychloride → HCID 59631348, compound

HRID 1431279Notes

Reaction equation

HRID 1431279 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8](=O)[CH2:9][CH3:10].[NH2:12][C:13]1[CH:21]=[C:20]([F:22])[C:19]([F:23])=[CH:18][C:14]=1[C:15](O)=O.P(Cl)(Cl)([Cl:26])=O>>[Cl:26][C:15]1[C:14]2[C:13](=[CH:21][C:20]([F:22])=[C:19]([F:23])[CH:18]=2)[N:12]=[C:8]([C:3]2[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=2[F:1])[C:9]=1[CH3:10]

Participants

4

Reactant 3

HCID 24813Phosphorus oxychlorideHCID 5793991-(2-Fluorophenyl)propan-1-oneHCID 7359652-Amino-4,5-difluorobenzoic acid

Product 1

HCID 59631348HCID 59631348, compound

Procedure

Prepared according to Procedure J using 1-(2-fluorophenyl)propan-1-one and 2-amino-4,5-difluorobenzoic acid in phosphorous oxychloride to afford a colorless solid upon purification by chromatography on silica gel. Mass Spectrum (ESI) m/e=308.0 (M+1).

Workup

  1. customPrepared
  2. customto afford a colorless solid
  3. customupon purification by chromatography on silica gel

Sources & evidence

ORD record
ord-2e0550e4fd1843a187f3a21cf43154e3
Source dataset
uspto-grants-2015_01
Patent number
US08940724B2

Reaction notes

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