Piperidine → 4-Chloro-5,7-difluoro-3-methyl-2-(piperidin-1-yl)quinoline

HRID 1431304Notes

Reaction equation

HRID 1431304 reaction equation
Cl[C:2]1[C:11]([CH3:12])=[C:10]([Cl:13])[C:9]2[C:4](=[CH:5][C:6]([F:15])=[CH:7][C:8]=2[F:14])[N:3]=1.[NH:16]1[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1>>[Cl:13][C:10]1[C:9]2[C:4](=[CH:5][C:6]([F:15])=[CH:7][C:8]=2[F:14])[N:3]=[C:2]([N:16]2[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]2)[C:11]=1[CH3:12]

Participants

3

Reactant 2

HCID 8082PiperidineHCID 596310402,4-Dichloro-5,7-difluoro-3-methylquinoline

Product 1

HCID 596311534-Chloro-5,7-difluoro-3-methyl-2-(piperidin-1-yl)quinoline

Procedure

Prepared according to Procedure G using 2,4-dichloro-5,7-difluoro-3-methylquinoline (300 mg, 1.21 mmol) and piperidine in to give 4-chloro-5,7-difluoro-3-methyl-2-(piperidin-1-yl)quinoline. Mass Spectrum (ESI) m/e=297.1 (M+1).

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-154a19155c204e10b32e6597e5c20903
Source dataset
uspto-grants-2015_01
Patent number
US08940724B2

Reaction notes

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