反应详情

温度

0 °C

To a stirred solution of 5-chloro-2-fluoro-3-nitropyridine (5 g, 28 mmol) in THF (40 mL) was added morpholine (4 mL, 42 mmol). The reaction was stirred at 0° C. for ten min, at rt for 1 h, and refluxed for four h. The reaction was then cooled to rt, taken up in EtOAc, and washed with satd aq. sodium bicarbonate and brine. The organic layer was dried (magnesium sulfate) and concentrated, affording 4-(5-chloro-3-nitropyridin-2-yl)morpholine as a yellow oil. Mass Spectrum (ESI) m/e=244.0 (M+1).

1. temperaturerefluxed for four h
2. temperatureThe reaction was then cooled to rt
3. washwashed with satd aq. sodium bicarbonate and brine
4. dry with materialThe organic layer was dried (magnesium sulfate)
5. concentrationconcentrated