HCID 59631518, compound → 3-(2-Chloro-5-fluorophenylamino)-2-methyl-3-oxopropanoic acid

HRID 1431467Notes

Reaction equation

HRID 1431467 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[NH:9][C:10](=[O:18])[CH:11]([CH3:17])[C:12]([O:14]CC)=[O:13]>C1COCC1>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([F:8])=[CH:4][C:3]=1[NH:9][C:10](=[O:18])[CH:11]([CH3:17])[C:12]([OH:14])=[O:13]

Participants

3

Reactant 1

HCID 59631518HCID 59631518, compound

Product 1

HCID 596310483-(2-Chloro-5-fluorophenylamino)-2-methyl-3-oxopropanoic acid

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The acid was prepared according to Procedure B using ethyl 3-(2-chloro-5-fluorophenylamino)-2-methyl-3-oxopropanoate (5.0 g, 18.27 mmol) in THF (18.3 mL) to give 3-(2-chloro-5-fluorophenylamino)-2-methyl-3-oxopropanoic acid. Mass Spectrum (ESI) m/e=245.9 (M+1).

Workup

  1. customThe acid was prepared

Sources & evidence

ORD record
ord-190bcf92d332477a9f9735ba54ad18b0
Source dataset
uspto-grants-2015_01
Patent number
US08940724B2

Reaction notes

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