Ethyl 3-(2-chloro-3,5-difluorophenylamino)-2-methyl-3-oxopropanoate → 3-(2-Chloro-3,5-difluorophenylamino)-2-methyl-3-oxopropanoic acid

HRID 1431471Notes

Reaction equation

HRID 1431471 reaction equation
[Cl:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([F:9])=[CH:4][C:3]=1[NH:10][C:11](=[O:19])[CH:12]([CH3:18])[C:13]([O:15]CC)=[O:14]>C1COCC1>[Cl:1][C:2]1[C:7]([F:8])=[CH:6][C:5]([F:9])=[CH:4][C:3]=1[NH:10][C:11](=[O:19])[CH:12]([CH3:18])[C:13]([OH:15])=[O:14]

Participants

3

Reactant 1

HCID 59631036Ethyl 3-(2-chloro-3,5-difluorophenylamino)-2-methyl-3-oxopropanoate

Product 1

HCID 596313193-(2-Chloro-3,5-difluorophenylamino)-2-methyl-3-oxopropanoic acid

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The acid was prepared according to Procedure B using ethyl 3-(2-chloro-3,5-difluorophenylamino)-2-methyl-3-oxopropanoate (5.0 g, 17.14 mmol) in THF (17.1 mL) to give 3-(2-chloro-3,5-difluorophenylamino)-2-methyl-3-oxopropanoic acid. Mass Spectrum (ESI) m/e=264.0 (M+1).

Workup

  1. customThe acid was prepared

Sources & evidence

ORD record
ord-c35a801a14a540b7beb5c6d04579fa85
Source dataset
uspto-grants-2015_01
Patent number
US08940724B2

Reaction notes

Loading…