反应详情

温度

22.5 °C

To a mixture of the compound obtained in Example 22 (1) (3.4 g), tetrahydrofuran (90 ml) and water (45 ml), OXONE (registered trademark) (8.7 g) was added at 0° C. and the mixture was stirred for 20 minutes and at 15 to 30° C. for 1 hour. The mixture was diluted with ethyl acetate. The organic layer was washed with water and dried over sodium-sulfate. The solvent was distilled off under reduced pressure to obtain 3.5 g of a white amorphous 1-benzenesulfonyl-5-methanesulfonylindole-2-carboxylic acid methyl ester as a crude product, which was used in the next reaction without; further purification.

1. additionwas added at 0° C.
2. washThe organic layer was washed with water
3. dry with materialdried over sodium-sulfate
4. distillationThe solvent was distilled off under reduced pressure